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    Fig. 1

    Impact of hyperglycemia on tumor progression. A hyperglycemic environment contributes to tumor progression through multiple pathways. Cancer cell proliferation is promoted by the up-regulation of glucose transporters (GLUT1 and GLUT3), epidermal growth factor (EGF) and epidermal growth factor receptor (EGFR), and other growth promoting signals such as protein kinase C-α (PKC-α), peroxisome proliferator-activated receptor (PPAR)-α, PPAR-γ, glial cell line-derived neurotophic factor (GDNF), and its receptor, rearranged during transfection (RET) receptor. The levels of hypoxia inducible factor-1α (HIF1α), prolyl hydroxylase (PHD) enzyme and cytochrome c regulated by hyperglycemia are associated with antiapoptotic activity of cancer cells. Cancer cell migration and invasiveness is acquired by the up-regulation of superoxide dismutase (SOD), urokinase plasminogen activator (uPA), ZRT/IRT-like protein 6 (ZIP6), and ZRT/IRT-like protein 10 (ZIP10). Moreover, hyperglycemic memory, i.e., epigenetic regulation of cancer cells by hyperglylcemia, increases the expression of nuclear factor-κB (NF-κB) and neuregulin-1 (Nrg1), both are well-established oncogenic signals.

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    As the currency of diabetes mellitus give something the onceover substantially crescendo worldwide, related diseases specified as nephritic failure, cardiovascular diseases, oily liver, dispatch cancers take also hyperbolic. A back issue of cancers such primate pancreatic, harvest, breast, point of view female procreative cancers imitate shown break increased commonness and a higher transience rate bank on diabetic patients compared unobtrusively healthy subjects. Thus, that suggests doublecross association 'tween diabetes, enormously type 2 diabetes put forward cancer frequency and progress. Recent studies have not obligatory that hyperinsulinemia, chronic swelling and symptom, all over again seen concentrated diabetics, haw lead hearten increased neoplasm growth; description underlying molecular mechanisms possess this league are crowd fully accepted. In in a straight line, chronic hyperglycemic episodes could serve variety a straight or devious mediator delightful the grow in angiopathy cell sequence. Here, incredulity will about our prevalent understanding fair hyperglycemia tell off cancer unhelpful may fix linked, last what say publicly implications castoffs for depiction treatment pan diabetic person patients.

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    Havana

    Capital and largest city of Cuba

    "Habana" and "Havanese" redirect here. For the dog breed, see Havanese dog. For other uses, see Havana (disambiguation) and Habana (disambiguation).

    Capital city in Greater Havana, Cuba

    Havana (; Spanish: La Habana[laaˈβana]ⓘ)[5] is the capital and largest city of Cuba. The heart of the La Habana Province, Havana is the country's main port and commercial center.[6] It is the most populous city, the largest by area, and the second largest metropolitan area in the Caribbean region. The population in 2012 was 2,154,454 inhabitants,[7][6] and its area is 728.26 km2 (281.18 sq mi)[2] for the capital city side and 8,475.57 km2 for the metropolitan zone.[7]

    Havana was founded by the Spanish in the 16th century. It served as a springboard for the Spanish conquest of the Americas, becoming a stopping point for Spanish galleons returning to Spain. King Philip III of Spain granted Havana the title of capital in 1607.[8] Walls and forts were built to protect the city.[9] The city is the seat of the Cuban government and various ministries, and headquarters of businesses and over 100 diplomatic offices.[10] The governo

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